Agenda, June 16, 2018
UC San Diego campus, Medical Education and Telemedicine Building
The goals of this meeting are to:
- Discuss progress of harmonizing the Opioid Genetics cohorts
- Discuss the phenotypes used for genetics studies in humans
- Discuss the phenotypes used for genetics studies in animal models
- Identify the synergies and gaps in the phenotypic analysis of humans and animal models
- Identify strategies to integrate genetics and genomics data with phenotypes across species to better understand the biology of substance use disorders and phenotypes associated with addictive behaviors
Schedule:
9:00 Laura Bierut: State of the science for human studies – Triumphs, limitations, opportunities
9:15 Olivier George: Phenotypes to examine in animal models, what can be measured?
9:30 Howard Edenberg: PGC Update
9:45 Tamara Phillips: Background genetics/modifier screens. What can they tell us? What implications does this have for GWAS studies
10:00 Break
10:15 Eric Johnson: Update from the Meta-analysis
10:30 Abraham Palmer: Strategies to Dissect the genetics of various phenotypes associated with SUD from multiple species: Are we measuring the right phenotype?
10:45 Vanessa Troiani / Wade Berrettini: Capitalizing on Large Health Systems to understand prescription opioid addiction
11:00 Robert Hitzemann: Accounting for differences in genetic findings for alcohol In humans and rodents
11:15 Breakout
Questions:
- How can animal models be best integrated with human genetic studies?
- Which phenotypes should be prioritized? How can we correlate animal and human phenotypes?
- What are the most effective way to use EHRs to understand the genetics of SUD? What are the advantages? Limitations?
- What is needed in future studies to harmonize opioid genetics cohorts (and other large SUD cohorts?)
12:15 Lunch
1:45 Susan Tapert: Updates from the ABCD Study
2:00 Huda Akil: Elucidating the genetics of SUD using animal models
2:15 Dan Larach: Analysis of Persistent Opioid Use in a Surgical Patient Cohort
2:30 Elissa Chesler: Integrating human and rodent data
2:45 Breakout
Questions:
- What are the synergies in the phenotypic analysis of human and animal models?
- What are the gaps and challenges to integrate human and animal models?
- What are strategies to integrate genetics and genomics data with phenotypes across species?
- How should we prioritize integration? Which phenotypes should we integrate first?
3:45 Sesh Mudumbai: SUD and Pain Phenotypes in the Million Veteran Program and at the VA
4:00 Laura Saba: Gene Weaver – A platform for understanding the genetics of SUD
4:15 Danielle Dick: Gene x Environment Interplay in alcohol use disorders
4:30 Gary Peltz: Computational models for identifying genetic factors in SUD
4:45 Report back from Breakouts
5:30 Adjourn
Review: Genes, Brain and Behavior
National Institute on Drug Abuse genomics consortium white paper: Coordinating efforts between human and animal addiction studies
First published: 23 April 2019