Grants related to this Center

The Center for GWAS in outbred rats has established key core services (Admin Core, Breeding Core, Sequencing/GBS Core and Pilot Project Core) that have given rise to a rich research ecosystem.

By far the greatest source of support have been U01 grants that were in response to PAR-15-120 “Identification of Genetic and Genomic Variants by Next-Gen Sequencing in Non-human Animal Models (U01)”. These projects have used the Breeding Core to provide HS rats and the Sequencing/GBS Core to perform genotyping and have also tapped into the expertise developed by Research Project 4. All of these grants were fostered by preliminary data collected with the help of pilot project grants from Core D.

Additional grants from NIDA and NIAAA have used the HS breeding core.

Finally, several grants have now arisen from our ancillary phenotyping project, in which tissues from the dissected HS rats were shared with investigators whose primary interest was in physiological phenotypes.

Multiple other grants that fit one of these three profiles are currently under consideration.

 InvestigatorsGrant #Grant TitleFunded by
1 Olivier George, PhD
0000-0002-3700-5003
University of California - San Diego

Abraham Palmer, PhD
0000-0003-3634-0747
University of California - San Diego
U01DA043799Identification of Genetic Variants that Contribute to Compulsive Cocaine Intake in Rats
NIDA/NIH
2 Olivier George, PhD
0000-0002-3700-5003
University of California - San Diego
U01DA044451Use of Next-Gen Sequencing to Identify Genetic Variants that Influence Compulsive Oxycodone Intake in Outbred Rats
NIDA/NIH
3 Thomas Jhou, PhD
0000-0001-8811-0156
Medical University of South Carolina
U01DA044468Genomic analysis of avoidance learning in addiction
NIDA/NIH
4 Huda Akil, PhD
0000-0003-0623-1056
University of Michigan

Jun Li , PhD
0000-0001-6727-0812
University of Michigan
U01DA043098Genetics of Novelty seeking and Propensity for Drug Abuse in Outbred Rats
NIDA/NIH
5 Peter Kalivas, PhD 0000-0001-9487-0119
Medical University of South Carolina
U01DA045300The Genetic Basis of Opioid Dependence Vulnerablility in a Rodent ModelNIDA/NIH
6Shelly Flagel, PhD
0000-0002-7309-9908
University of Michigan
R01DA038599Dynamic Control of Cue-Driven Behavior Via the Paraventricular Thalamic Nucleus
NIDA/NIH
7 Paul Meyer, PhD
0000-0001-5665-2292
University at Buffalo
R01AA024112
Nicotine amplification of behavioral and neural responses to alcohol cuesNIAAA/NIH
8 Douglas Adams, PhD
0000-0002-6090-0516
University of Colorado
R01AR070879Identification of Genes Regulating Bone Matrix Composition and Quality
NIAMS/NIH
9 Leah Solberg-Woods, PhD
0000-0002-7943-798X
Wake Forest University

Kevin R. Regner, MD, MS, FASN
Medical College of Wisconsin
AHW

Genetic Mapping and Gene Identification in Acute Kidney Injury Using Outbred Rats
MCW, Advancing Healthier Wisconsin Endowment
10Abraham Palmer, PhD
0000-0003-3634-0747
University of California - San Diego
CMI Seed GrantGenetics of microbiome in HS ratsUCSD, Center for Microbiome Innovation
11Suzanne Mitchell, PhD
0000-0002-0225-7200
Oregon Health & Science University
U01DA046077Identification of Genetic Features of Delay Discounting Using a Heterogeneous Stock Rat ModelNIDA/NIH
12Shelly Flagel, PhD
0000-0002-7309-9908
University of Michigan
R21DA045146Identification of Neurochemical Antecedents and Consequences of Distinct Learning Processes Relevant to Addiction LiabilityNIDA/NIH
13Monika Jablonsky, PhD
University of Tennessee Health Science Center
R01EY021200Genetic Modulators of GlaucomaNEI/NIH
14Francesca Telese, PhD
0000-0003-3877-0628
University of California - San Diego
U01DA050239
SINGLE-CELL RESOLUTION ANALYSIS OF CHROMATIN ACCESSIBILITY AND GENE EXPRESSION CHANGES IN A MODEL OF DRUG ADDICTIONNIDA/NIH
15 Leah Solberg-Woods, PhD
0000-0002-7943-798X
Wake Forest University
R01DK120667Systems genetics to identify neuronal genes for diet-induced obesityNIDDK/NIH
16Abraham Palmer, PhD
0000-0003-3634-0747
University of California - San Diego
Melissa Gymrek, PhD
0000-0003-3634-0747
University of California - San Diego
Jonathan Sebat, PhD
0000-0002-9087-526X
University of California - San Diego
U01DA051234
Characterization of Tandem Repeat and Structural Variants Contributing to Addictive Behaviors in Mice and RatsNIDA/NIH
17Francesca Telese, PhD
0000-0003-3877-0628
University of California - San Diego
U01DA051972
Decoding the grammar of transcriptional enhancers regulating different stages of opioid use disorderNIDA/NIH
18J. Andrew Pospisilik, Ph.D
0000-0002-9745-0977
Van Andel Research Institute, Grand Rapids, MI
Joseph Nadeau, Ph.D
0000-0002-9570-7361
Maine Medical Center Research, ME
Transformative Research Award
R01 HG012444

Master Regulators of Unexplained Variation in Disease Risk NIH Office of Director
19Amelie Baud, Ph.D
0000-0003-2448-0283
Centre for Genomic Regulation, Barcelona, Spain
LCF/BQ/PI21/11830006
Systems genetics analysis of host-microbiome interactions in genetically heterogeneous laboratory rats“la Caixa” Foundation (Barcelona, Spain)
20 Giordano de Guglielmo, PhD
0000-0003-1024-4116
University of California - San Diego

Hae Kyung Im, PhD
0000-0001-9163-927X
University of Chicago
R01AA029688A
A Framework for Translating Polygenic Findings Related to Alcohol Use Disorder Across SpeciesNIAAA/NIH
21 Seyoung Kim, PhD
0000-0003-1024-4116
Carnegie Mellon University
NSF 2154089Computational methods for allele-specific expression quantificationCarnegie Mellon University,
NSF