The Center for GWAS in outbred rats has established key core services (Admin Core, Breeding Core, Sequencing/GBS Core and Pilot Project Core) that have given rise to a rich research ecosystem.
By far the greatest source of support have been U01 grants that were in response to PAR-15-120 “Identification of Genetic and Genomic Variants by Next-Gen Sequencing in Non-human Animal Models (U01)”. These projects have used the Breeding Core to provide HS rats and the Sequencing/GBS Core to perform genotyping and have also tapped into the expertise developed by Research Project 4. All of these grants were fostered by preliminary data collected with the help of pilot project grants from Core D.
Additional grants from NIDA and NIAAA have used the HS breeding core.
Finally, several grants have now arisen from our ancillary phenotyping project, in which tissues from the dissected HS rats were shared with investigators whose primary interest was in physiological phenotypes.
Multiple other grants that fit one of these three profiles are currently under consideration.
| Investigators | Grant # | Grant Title | Funded by | |
|---|---|---|---|---|
| 1 | Olivier George, PhD University of California - San Diego Abraham Palmer, PhD University of California - San Diego | U01DA043799 | Identification of Genetic Variants that Contribute to Compulsive Cocaine Intake in Rats | NIDA/NIH |
| 2 | Olivier George, PhD University of California - San Diego | U01DA044451 | Use of Next-Gen Sequencing to Identify Genetic Variants that Influence Compulsive Oxycodone Intake in Outbred Rats | NIDA/NIH |
| 3 | Thomas Jhou, PhD Medical University of South Carolina | U01DA044468 | Genomic analysis of avoidance learning in addiction | NIDA/NIH |
| 4 | Huda Akil, PhD Jun Li , PhD University of Michigan | U01DA043098 | Genetics of Novelty seeking and Propensity for Drug Abuse in Outbred Rats | NIDA/NIH |
| 5 | Peter Kalivas, PhD Medical University of South Carolina | U01DA045300 | The Genetic Basis of Opioid Dependence Vulnerablility in a Rodent Model | NIDA/NIH |
| 6 | Shelly Flagel, PhD University of Michigan | R01DA038599 | Dynamic Control of Cue-Driven Behavior Via the Paraventricular Thalamic Nucleus | NIDA/NIH |
| 7 | Paul Meyer, PhD University at Buffalo | R01AA024112 | Nicotine amplification of behavioral and neural responses to alcohol cues | NIAAA/NIH |
| 8 | Douglas Adams, PhD University of Colorado | R01AR070879 | Identification of Genes Regulating Bone Matrix Composition and Quality | NIAMS/NIH |
| 9 | Leah Solberg-Woods, PhD Wake Forest University Kevin R. Regner, MD, MS, FASN Medical College of Wisconsin | AHW | Genetic Mapping and Gene Identification in Acute Kidney Injury Using Outbred Rats | MCW, Advancing Healthier Wisconsin Endowment |
| 10 | Abraham Palmer, PhD University of California - San Diego | CMI Seed Grant | Genetics of microbiome in HS rats | UCSD, Center for Microbiome Innovation |
| 11 | Suzanne Mitchell, PhD Oregon Health & Science University | U01DA046077 | Identification of Genetic Features of Delay Discounting Using a Heterogeneous Stock Rat Model | NIDA/NIH |
| 12 | Shelly Flagel, PhD University of Michigan | R21DA045146 | Identification of Neurochemical Antecedents and Consequences of Distinct Learning Processes Relevant to Addiction Liability | NIDA/NIH |
| 13 | Monika Jablonsky, PhD University of Tennessee Health Science Center | R01EY021200 | Genetic Modulators of Glaucoma | NEI/NIH |
| 14 | Francesca Telese, PhD University of California - San Diego | U01DA050239 | SINGLE-CELL RESOLUTION ANALYSIS OF CHROMATIN ACCESSIBILITY AND GENE EXPRESSION CHANGES IN A MODEL OF DRUG ADDICTION | NIDA/NIH |
| 15 | Anne E. Kwitek, PhD Medical College of Wisconsin Hans-Joachim Lehmler, PhD The University of Iowa | R01ES032312 | Systems genetics of bisphenol F (BPF)-induced obesity and metabolic disease | NIH/EHS |
| 16 | Leah Solberg-Woods, PhD Wake Forest University | R01DK120667 | Systems genetics to identify neuronal genes for diet-induced obesity | NIDDK/NIH |
| 17 | Abraham Palmer, PhD Melissa Gymrek, PhD Jonathan Sebat, PhD University of California - San Diego | U01DA051234 | Characterization of Tandem Repeat and Structural Variants Contributing to Addictive Behaviors in Mice and Rats | NIDA/NIH |
| 18 | Francesca Telese, PhD University of California - San Diego | U01DA051972 | Decoding the grammar of transcriptional enhancers regulating different stages of opioid use disorder | NIDA/NIH |