• MCW Gene Editing Rat Resource Center announced 6th round of applications for genetically modified rats. Deadline is Sept 16, 2016

The National Heart, Lung, and Blood Institute (NHLBI) has awarded the Medical College of Wisconsin an R24 Resource grant to make ~200 genetically modified rat strains over the next five years. These models will be of interest and value to the mission of the NHLBI. The NHLBI promotes the prevention and treatment of heart, lung, and blood diseases through scientific discovery directed toward the causes of disease and translation of basic discoveries into clinical practice.

Round 6 Deadline: September 16, 2016 (Midnight Milwaukee, WI time). Submit completed application to: mcwcustomrats@mcw.edu.

Applications: Instructions, applications (in PDF and Word format), and a sample application can be accessed on the GERRC website (http://rgd.mcw.edu/wg/gerrc) or attached to this email.

Decision on Applications: October 2016

Number of Applications that can be submitted: Up to two per laboratory or PI.

Number of Applications that will be awarded: Up to 25 meritorious applications.

Application review: An External Advisory Board (EAB) and staff from the National Heart, Lung, and Blood Institute (NHLBI) will review completed applications. The EAB will determine the successful applications and the priority of when the models will be made.

Animal Delivery date (Assuming success): 9 to 12 months after acceptance for many animal models.

Cost to investigator: Cost to raise each animal to age of shipping, plus shipping costs and any requested pathological tests on animals not covered by our standard Biomedical Resource Center survey program.

Distribution of Animals: The PI of the successful application will receive the first breeder pair. All other breeder pairs will be sent on a first come, first served basis to any other requesting investigator. There is NO priority period. When we receive the first heterozygous breeding pair the investigator will be notified and requested to begin making arrangements for shipment. At this time the web site (http://rgd.mcw.edu/wg/gerrc) will be updated to indicate that a new model will be available. The strain and mutation/modification will be posted.

Materials Transfer Agreement (MTA): The Applicant will be required to sign a materials transfer agreement. Animals may not be sold or used for commercial activities.

Frequency of Applications: We anticipate two competitive application deadlines per year.