C-GORD (The Center for GWAS in Outbred Rats Database) provides access to the data generated by the NIDA Center for Genetic Studies of Drug Abuse in Outbred Rats (P50DA037844) and more than 10 additional research projects that use N/NIH heterogeneous stock (HS) outbred rats and the Center’s core services that support genotyping and analysis.
C-GORD’s goal is to align data generated in HS rats with the FAIR (Findable, Accessible, Interoperative, Reusable) data management principles.
Several types of data are available for HS rats: multiple behavior phenotypes (most of them related to drug addiction behaviors), multiple physiological phenotypes, genotypes, gene expression, microbiome and metabolomics.
C-GORD provides structured access to the data associated with the research papers produced by research projects that use HS rats.
(Note: C-GORD is currently in revision.
Lists of project and publication datasets available here during transition.)
Findable, Accessible, Interoperable, Reusable data generated by the NIDA Center for Genetic Studies of Drug Abuse in Outbred Rats.
Improving our understanding of genetic susceptibility
NIDA Center for Genetic Studies of Drug Abuse in Outbred Rats (P50DA037844)
There are few effective therapies to treat drug abuse and dependence, despite the urgent need to develop more effective treatments. A major impediment to the development of such treatments is our extremely limited understanding of the biological basis of drug abuse.
While human genome-wide association studies (GWAS) have begun to elucidate genes that influence various traits relevant to drug abuse, they are still unable to attribute more than a small fraction of the heritable variance to specific genes. NIDA Center for Genetic Studies of Drug Abuse in Outbred Rats (P50DA037844) was created in 2014 to perform GWAS on numerous behavioral traits that have well-established relevance to drug abuse using outbred rats. The Center was successfully renewed in 2019. We expect to discover new genes that can influence drug abuse-related behaviors in rats, therefore improving our understanding of genetic susceptibility to drug abuse in humans. Our results will help to identify new opportunities to treat psychiatric disorders, including addiction.
Request access to secured data
Please contact us or complete this form if you’re interested in using the data and please indicate which dataset(s). We’ll review your request and respond with the necessary credentials to access the requested dataset(s). By requesting access to the data, you agree to our license.
CONTACT
Abraham Palmer : [email protected]
Oksana Polesskaya : [email protected]
Click here to learn more about rat genes on RatGTeX
Click here to learn more about the Palmer Lab
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