Datasets are available on this web page. Datasets are not available on the C-GORD website/portal. C-GORD was accessible 2021-2025; the website/domain is no longer affiliated with the Center for Genetics, Genomics, and Epigenetics of Substance Use Disorders in Outbred Rats.
Here we provide access to the data associated with the research papers produced by research projects that use HS rats.
These lists are in revision and will continue to update as we transition.
Last update:
Publication Datasets
| Title | Author | Publication | Publication Year | PubMed PMID | Links |
|---|---|---|---|---|---|
| Genome-Wide Association Study in 3,173 Outbred Rats Identifies Multiple Loci for Body Weight, Adiposity, and Fasting Glucose | Chitre, AS et al. | Obesity | 2020 | 32860487 | Manuscript |
| Genome-Wide Association Study on Three Behaviors Tested in an Open Field in Heterogeneous Stock Rats Identifies Multiple Loci Implicated in Psychiatric Disorders | Gunturkun, MH et al. | Frontiers in Psychiatry | 2022 | 35237186 | Manuscript |
| The regulatory landscape of multiple brain regions in outbred heterogeneous stock rats | Munro, D et al. | Nucleic Acids Research | 2022 | 36263809 | Manuscript |
| Y and Mitochondrial Chromosomes in the Heterogeneous Stock Rat Population | Okamoto, F et al. | G3: Genes, Genomes, Genetics | 2024 | 39250761 | Manuscript |
| Genome-wide association studies of human and rat BMI converge on synapse | Wright, SN et al. | Cell Reports | 2023 | 37527041 | Manuscript |
| Genome-wide association study of delay discounting in Heterogeneous Stock rats | Lara, MK et al. | Genes, Brain and Behavior | 2024 | 39119916 | Manuscript |
| Genome-wide association study reveals multiple loci for nociception and opioid consumption behaviors associated with heroin vulnerability in outbred rats | Kuhn, B et al. | Molecular Psychiatry | 2025 | 40000848 | Manuscript Genotypes |
| A Cost-effective, High-throughput, Highly Accurate Genotyping Method for Outbred Populations | Chen, D et al. | G3: Genes, Genomes, Genetics | 2025 | 39670731 | Manuscript |
Project Datasets
| Project Number | Project Title | Project Dates | Phenotypes | Omics Data | Sample Size |
|---|---|---|---|---|---|
| U01DA051234 | Characterization of Tandem Repeat and Structural Variants Contributing to Addictive Behaviors in Mice and Rats | ||||
| U01DA050239 | Single-cell resolution analysis of chromatin accessibility and gene expression | 5/1/2020-2/28/2025 | RNA-seq ATAC-seq H3K27Ac PLAC-seq | 96 | |
| U01DA044468 | Genomic analysis of avoidance learning in addiction | 4/15/2018 | Avoidance-Learning | RNA-Seq | Goal: 1200 Current: 1239 |
| U01DA044451 | Genetics of Compulsive Oxycodone Intake in HS Rats | 8/13/2019 | Oxycodone infusions Reward intake Tail immersion Lever presses | Goal: 1000 Current: 619 |
|
| U01DA043799 | Genetics of Compulsive Cocaine Intake in Rats | 4/1/2017 | Addiction Index Aggression Behavior Defensive Behavior Behavior Stability Cocaine Intake | Goal: 1000 Current: 882 | |
| U01DA046077 | Genetic Features of Delay Discounting in an HS Rat Model | 7/1/2018 | Delay Discounting Impulsivity 5-choice serial reaction time task | RNA-Seq | Goal: 1560 Current: 901 |
| U01DA045300 | Genetic Basis of Opioid Dependence Vulnerablility | 9/30/2018 | Self-administration Drug-seeking | RNA-Seq | Goal: 1000 Current: 655 |
| U01 | Decoding the grammar of transcriptional enhancers regulating different stages of opioid use disorder | 9/30/2020 | RNA-Seq ATAC-seq | RNA-Seq | |
| Structural equation modeling for understanding the genetic architecture of cocaine contextual conditioning and cocaine conditioned cue preference in heterogeneous stock rats undercover candidate genes for behavioral variation caused by cocaine exposure | TBD | Cocaine contextual conditioning Cocaine conditioned cue preference | 3050 | ||
| R01 | Identification of Genes Regulating Bone Matrix Composition and Quality | Bone density | Goal = 4800 | ||
| P50DA037844, Project 4 | Network-based analysis | 2019-2024 | various | ||
| P50DA037844, Project 3 | Association between behavioral regulation and cocaine cue preference | 2014-2024 | Locomotor Response Delay Discounting Light Reinforcement Locomotor Activity Reaction time Social Reinforcement Enriched Environment Pavlovian Conditioned Approach | Goal: 1600 Current: 1066 |
|
| P50DA037844, Project 2 | Socially-acquired nicotine self-administration | Open Field Novel Object Interaction Test Nicotine self-administration Progressive ratio testing | Goal: 4800 Current: 2600 |
||
| P50DA037844, Project 1 | Neurogenetic Substrates of Cocaine Addiction | 2019-2024 | Intermittent access to cocaine | RNA-Seq | Goal: 1600 Current: 1911 |
| P50DA037844, Project 1 | Genetic Studies of Incentive Salience | 2014-2019 | Cocaine Contextual Conditioning Novelty seeking Pavlovian Conditioned Approach | 1600 |
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CONTACT
Abraham Palmer : aap@ucsd.edu
Oksana Polesskaya : opolesskaya@ucsd.edu
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