A new U01 grant from the National Institute on Drug Abuse (NIDA) was awarded to Dr. Pejman Mohammadi and Dr. Abraham Palmer.
The grant is titled “Deep Analysis of Transcriptome to Understand the Genetics of Substance Use Disorders in Rats” (U01DA060443) and it will start July 1, 2025 and end on March 31, 2030.
Drs. Mohammadi and Palmer and their research collaborators will improve the molecular interpretation of GWAS results from SUD-related phenotypes by expanding integrative genome and transcriptome analysis in rats to a wide range of transcriptional phenotypes, including but not limited to transcript isoform usage, lncRNA expression, alternative transcription start, and polyA sites, exon skipping, intron retention, and RNA stability; produce an unprecedented atlas of variation in rat transcriptome as a mediator of SUD-relevant traits; integrate these findings with SUD-related GWAS data to facilitate the identification of specific genes and provide a molecular understanding of SUD that will identify new novel drug targets.
Congratulations!